Typical dose
Typically 250-500 mg of the phytosome complex (e...
Oral
Oral safety: low
About this supplement
Berberine Phytosome/Phospholipid Complex is an advanced delivery form of the alkaloid berberine, where berberine is complexed with phospholipids (typically phosphatidylcholine) to form a phytosome. This complexation significantly enhances the bioavailability, absorption, and stability of berberine compared to standard berberine extracts. The phospholipid envelope mimics cell membranes, facilitating improved gastrointestinal absorption and cellular uptake. It is primarily used as an oral supplement for metabolic and cardiovascular support.
How much to take
- Typical amount
- Typically 250-500 mg of the phytosome complex (equivalent to lower doses of berberine due to enhanced bioavailability) taken 1-2 times daily with meals.
- Suggested range
- 250-1000 mg daily (of the phytosome complex)
Potential benefits
Benefits linked to this supplement form:
Things to watch for
Possible side effects linked to this form:
Health goals
Needs and goals this form may help with:
Other forms of Berberine
Compare absorption and active amounts with sibling forms:
Technical details â–¼
Chemical ID (CAS)
2086-83-1 (berberine chloride); complex form may not have unique CAS
Formula
C20H18NO4 (berberine base) - complexed with phospholipids (e.g., C42H80NO8P for phosphatidylcholine)
Physical properties
Typically a yellow to brown powder or granular solid. Improved solubility in both water and lipids due to phospholipid complexation. More stable than pure berberine salts.
How it’s made
Produced by reacting berberine extract (usually from berberine hydrochloride or sulfate) with phospholipids (most commonly phosphatidylcholine from soy or sunflower) in an aprotic solvent. The complex forms via hydrogen bonding and other interactions, creating a lipid-compatible molecular complex. The solvent is removed, and the resulting complex is dried and milled into powder.