Typical dose
500-1500mg daily, divided into 2-3 doses with me...
Oral
Oral safety: low
About this supplement
Berberine sulfate is the sulfate salt form of berberine, an isoquinoline alkaloid derived from various medicinal plants. This specific chemical form enhances the solubility and bioavailability of berberine compared to its free base form. Berberine sulfate functions as a metabolic modulator, primarily known for activating AMP-activated protein kinase (AMPK), which regulates cellular energy homeostasis. It exhibits broad pharmacological activities including antimicrobial, anti-inflammatory, antidiabetic, and lipid-lowering effects. The sulfate salt form provides improved stability and absorption characteristics for oral supplementation.
How much to take
- Typical amount
- 500-1500mg daily, divided into 2-3 doses with meals
- Suggested range
- 300-500mg two to three times daily
Potential benefits
Benefits linked to this supplement form:
Things to watch for
Possible side effects linked to this form:
Health goals
Needs and goals this form may help with:
Other forms of Berberine
Compare absorption and active amounts with sibling forms:
Technical details â–¼
Chemical ID (CAS)
633-66-9
Formula
C20H18NO4·H2SO4
Physical properties
Yellow to orange crystalline powder, soluble in water and ethanol, hygroscopic, melting point approximately 200-205°C with decomposition, typically >95% purity in supplement forms.
How it’s made
Typically extracted from plant sources (Berberis species, Coptis chinensis, Hydrastis canadensis) using solvent extraction, followed by purification and conversion to sulfate salt through reaction with sulfuric acid. May also be produced semi-synthetically through chemical synthesis of berberine followed by salt formation.