botanical Botanicals Oral

Berberine

A plant-derived alkaloid with significant research supporting its role in supporting healthy blood sugar and lipid metabolism.

Sci.Berberine 10 mg berberine &5000 mcg of berberine berberine berberine 97% extract berberine alkaloids berberine cyclodextrin complex berberine extract berberine hcl berberine hcl dihydrate berberine hcl extract powder berberine hcl powder berberine hplc berberine hydrochloride berberine hydrochloride dihydrate berberine hydrochloride hydrate berberine hydrochloride, powder berberine phospholipid complex berberine phytosome berberine root extract berberine, soluble {berberine} sulfate berberine (sulfate) berberine sulfate berberine sulfate 250 mg berberine sulfate extract berberine sulfate hydrate berberine sulphate berberine yellow gold berberpure berberpure berberine hcl berbevis dihydroberberine glucovantage min. 1 mg berberine min. 2.4 mg berberine standardized for 5000 mcg of berberine super berberine 5000 mcg of berberine
4 forms
Oral

About Berberine

Berberine is a bioactive isoquinoline alkaloid compound derived from various plants, primarily from the Berberis species, Coptis chinensis, and Hydrastis canadensis. It is extensively researched for its effects on metabolism and cardiovascular health, particularly through the activation of AMP-activated protein kinase (AMPK), which plays a crucial role in regulating glucose and lipid metabolism and influencing gut microbiota.

Official resources

Fact sheets from the NIH Office of Dietary Supplements related to this ingredient group.

Dietary Supplement Label Database

Ingredient group data in NutriNav is aligned with the NIH Dietary Supplement Label Database (DSLD).

DSLD group id
6975

At a glance

Approval status

supplement

Compare All Forms

4 forms

Compare supplement forms of Berberine by absorption quality and what your body actually gets from each:

High Moderate Low
Form Absorption Steps to absorb Notes Action
Berberine HCl (Hydrochloride)

Supports healthy blood sugar and cholesterol levels; consult...

  • UNII: 0I8Y3P32UF
  • CAS: 633-65-8
  • Label category: natural
 — — — View →
Berberine Phytosome/Phospholipid Complex

Enhanced absorption berberine for metabolic support

  • CAS: 2086-83-1 (berberine chloride); complex form may not have unique CAS
  • Label category: hybrid
 — — — View →
Berberine Sulfate

Metabolic support supplement derived from traditional medici...

  • CAS: 633-66-9
  • Label category: hybrid
 — — — View →
Dihydroberberine

Enhanced-absorption form of berberine for metabolic support

  • CAS: 117-04-8 (often referenced as berberine derivative; specific CAS for dihydroberberine chloride may vary)
  • Label category: hybrid
 — — — View →

Also appears on labels as

Additional names seen on supplement labels for forms of this ingredient (beyond the main aliases above).

Berberine-PC complex, Berberine chloride, Berberine phospholipid, Berberine sulfate salt, Berberinium sulfate, DHB, Dihydroberberine chloride, Reduced berberine

Type: Botanicals

Category for Botanicals ingredients

Watch out for

Possible interactions or cautions — talk to a healthcare provider if unsure.

  • May interact with anticoagulants, antihypertensives, and medications for diabetes.

Potential Benefits

Benefits associated with Berberine forms:

Cholesterol Reduction Blood Sugar Control Cardiovascular Support Anti-inflammatory Effects Blood Sugar Regulation Lipid Profile Improvement

And 11 more benefits...

Potential Side Effects

Side effects associated with Berberine forms:

Digestive Upset How serious: Mild Gastrointestinal Discomfort How serious: low Drug Interactions How serious: medium Hypoglycemia Risk How serious: medium Bilirubin Elevation in Infants How serious: high Berberine-induced Jaundice How serious: high

And 2 more side effects...

What does the research say?

Research indicates that berberine can effectively lower blood sugar levels, improve lipid profiles, and support metabolic health through its action on AMPK and gut microbiota modulation.