Typical dose
100-200 mg daily, often taken in divided doses w...
Oral
Oral safety: low
About this supplement
Dihydroberberine is a hydrogenated derivative of the natural alkaloid berberine, designed to improve bioavailability and pharmacokinetics. It is created by reducing the double bond in the berberine structure, resulting in a more stable and absorbable compound. Dihydroberberine is primarily researched for its metabolic and glucose-regulating effects, similar to berberine but with potentially enhanced efficacy due to better absorption and reduced first-pass metabolism. It functions as an AMP-activated protein kinase (AMPK) activator and may influence various metabolic pathways.
How much to take
- Typical amount
- 100-200 mg daily, often taken in divided doses with meals
- Suggested range
- 50-300 mg daily
Potential benefits
Benefits linked to this supplement form:
Things to watch for
Possible side effects linked to this form:
Health goals
Needs and goals this form may help with:
Other forms of Berberine
Compare absorption and active amounts with sibling forms:
Technical details â–¼
Chemical ID (CAS)
117-04-8 (often referenced as berberine derivative; specific CAS for dihydroberberine chloride may vary)
Formula
C20H18NO4+
Physical properties
Typically a yellow to orange crystalline powder. More lipophilic than berberine, leading to improved membrane permeability. Soluble in organic solvents like DMSO and ethanol, sparingly soluble in water.
How it’s made
Produced via chemical hydrogenation of berberine extracted from botanical sources (e.g., Berberis species). The process involves catalytic reduction of the iminium bond in berberine, often using sodium borohydride or similar reducing agents under controlled conditions.