Vitamin B6 (pyridoxine 5-phosphate)

Vitamin B6

Active coenzyme form of Vitamin B6; does not require liver activation.

Part of Vitamin B6 vitamin
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Typical dose

Typical supplemental doses range from 5-100 mg d...

Oral Oral safety: low

About this supplement

Vitamin B6 (pyridoxine 5-phosphate) is the active, phosphorylated coenzyme form of vitamin B6, specifically pyridoxal 5'-phosphate (PLP). This form is biologically active and serves as a cofactor in over 140 enzymatic reactions, primarily in amino acid metabolism, neurotransmitter synthesis (serotonin, dopamine, GABA), hemoglobin formation, and glycogenolysis. Unlike the inactive pyridoxine hydrochloride, pyridoxine 5-phosphate does not require conversion by the liver and is immediately available for cellular use, making it a preferred form for supplementation, especially for individuals with impaired liver function or specific genetic polymorphisms affecting conversion. It is water-soluble and must be obtained regularly from the diet or supplements.

How much to take

Typical amount
Typical supplemental doses range from 5-100 mg daily, often as part of a B-complex or multivitamin. Higher doses (up to 200 mg daily) are sometimes used under medical supervision for specific conditions.
Suggested range
1.3-100 mg daily

Potential benefits

Benefits linked to this supplement form:

Immune System Support

Research strength: Moderate

 Neurotransmitter Synthesis

Research strength: Very strong

 Homocysteine Metabolism

Research strength: Strong

 Hemoglobin Production

Research strength: Very strong

 Amino Acid Metabolism Support

Research strength: Very strong

 Immune Function Support

Research strength: Moderate

 Glycogenolysis Support

Research strength: Strong

 Red Blood Cell Formation

Research strength: Very strong

 Amino Acid & Protein Metabolism

Research strength: Very strong

 Hemoglobin Production & Anemia Prevention

Research strength: Strong

 Amino Acid Metabolism

Research strength: Very strong

 Nausea Relief in Pregnancy

Research strength: Strong

 Bioavailable B6 for Impaired Conversion

Research strength: Moderate

 Cognitive Function & Neurotransmitter Synthesis

Research strength: Strong

 Red Blood Cell Formation & Function

Research strength: Very strong

 Glycogen Breakdown & Gluconeogenesis

Research strength: Strong

 Hemoglobin Production & Anemia Support

Research strength: Strong

 Hormonal Regulation & PMS Symptom Relief

Research strength: Moderate

Things to watch for

Possible side effects linked to this form:

Gastrointestinal Discomfort

How serious: low

 Gastrointestinal Distress

How serious: low

 Neuropathy (High Dose)

How serious: high

 Photosensitivity

How serious: low

 Neuropathy (from high doses)

How serious: high

 Peripheral Neuropathy

How serious: high

 Peripheral Sensory Neuropathy

How serious: high

 Sensory Neuropathy

How serious: high

Health goals

Needs and goals this form may help with:

Other forms of Vitamin B6

Compare absorption and active amounts with sibling forms:

Pyridoxal 5'-Phosphate (PLP)

Active form of Vitamin B6; essential cofactor for numerous enzymes.
Vitamin B6 (P-5-P)

Active form of Vitamin B6; essential for protein metabolism & neurotransmitter s...
Vitamin B6 (pyridoxal)

Essential B-vitamin; active coenzyme form; supports protein metabolism, cognitiv...
Vitamin B6 (pyridoxine hydrochloride)

Essential vitamin for metabolism, nerve function, and red blood cell formation.
Vitamin B6 (pyridoxine)

Essential vitamin for metabolism, nerve function, and red blood cell formation.
Compare all forms in the table
Technical details â–¼

Chemical ID (CAS)

54-47-7

Formula

C8H10NO6P

Physical properties

Typically appears as a white to off-white crystalline powder. It is hygroscopic (absorbs moisture from air). Soluble in water, slightly soluble in ethanol, and insoluble in ether and chloroform. Sensitive to light, heat, and alkaline conditions.

How it’s made

Pyridoxal 5'-phosphate is produced synthetically for commercial use. The process typically involves the chemical phosphorylation of pyridoxine (or a derivative) followed by oxidation to yield the active aldehyde form. It is manufactured under controlled conditions to ensure purity and stability.