Vitamin B6 (pyridoxine hydrochloride)

Vitamin B6

Essential vitamin for metabolism, nerve function, and red blood cell formation.

Part of Vitamin B6 vitamin
Compare all forms

Typical dose

1.3-1.7 mg daily for adults (RDA). Supplemental...

Oral Oral safety: low

About this supplement

Vitamin B6 (pyridoxine hydrochloride) is the hydrochloride salt form of pyridoxine, a water-soluble vitamin belonging to the B-complex family. It serves as a coenzyme in over 100 enzymatic reactions, primarily involved in amino acid metabolism, neurotransmitter synthesis (e.g., serotonin, dopamine, GABA), hemoglobin formation, and glycogenolysis. This specific form, pyridoxine hydrochloride, is a stable, synthetic compound commonly used in dietary supplements and fortified foods due to its high bioavailability and stability. It is converted in the body to the active coenzyme forms pyridoxal 5'-phosphate (PLP) and pyridoxamine 5'-phosphate (PMP).

How much to take

Typical amount
1.3-1.7 mg daily for adults (RDA). Supplemental doses typically range from 10-100 mg daily.
Suggested range
1.3-100 mg daily

Potential benefits

Benefits linked to this supplement form:

Immune System Support

Research strength: Strong

 Neurotransmitter Synthesis

Research strength: Very strong

 Homocysteine Metabolism

Research strength: Strong

 Hemoglobin Production

Research strength: Very strong

 Amino Acid Metabolism Support

Research strength: Very strong

 Immune Function Support

Research strength: Moderate

 Amino Acid Metabolism

Research strength: Very strong

 Reduction of Pregnancy Nausea

Research strength: Strong

Things to watch for

Possible side effects linked to this form:

Gastrointestinal Discomfort

How serious: low

 Gastrointestinal Distress

How serious: low

 Photosensitivity

How serious: low

 Sensory Neuropathy

How serious: high

Health goals

Needs and goals this form may help with:

Other forms of Vitamin B6

Compare absorption and active amounts with sibling forms:

Pyridoxal 5'-Phosphate (PLP)

Active form of Vitamin B6; essential cofactor for numerous enzymes.
Vitamin B6 (P-5-P)

Active form of Vitamin B6; essential for protein metabolism & neurotransmitter s...
Vitamin B6 (pyridoxal)

Essential B-vitamin; active coenzyme form; supports protein metabolism, cognitiv...
Vitamin B6 (pyridoxine 5-phosphate)

Active coenzyme form of Vitamin B6; does not require liver activation.
Vitamin B6 (pyridoxine)

Essential vitamin for metabolism, nerve function, and red blood cell formation.
Compare all forms in the table
Technical details â–¼

Chemical ID (CAS)

58-56-0

Formula

C8H12ClNO3

Physical properties

White or almost white crystalline powder or colorless crystals. Freely soluble in water, slightly soluble in ethanol. Stable in air, but sensitive to light, especially in solution.

How it’s made

Produced synthetically via chemical synthesis. A common industrial route involves the Diels-Alder reaction of oxazole and maleic anhydride derivatives, followed by several steps including hydrolysis, amination, and finally treatment with hydrochloric acid to form the hydrochloride salt.