Vitamin B6 (P-5-P)

Vitamin B6

Active form of Vitamin B6; essential for protein metabolism & neurotransmitter synthesis.

Part of Vitamin B6 vitamin
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Typical dose

Typical supplemental doses range from 5-50 mg da...

Rating

0.0/5

Oral Oral safety: low

About this supplement

Vitamin B6 in its active coenzyme form, pyridoxal 5'-phosphate (P-5-P). It is the biologically active form of vitamin B6 that serves as a cofactor for over 100 enzymes, primarily involved in amino acid metabolism, neurotransmitter synthesis (serotonin, dopamine, GABA), hemoglobin formation, glycogenolysis, and immune function. Unlike pyridoxine hydrochloride, P-5-P does not require conversion by the liver and is immediately available for enzymatic reactions, making it particularly beneficial for individuals with impaired conversion enzymes.

How much to take

Typical amount
Typical supplemental doses range from 5-50 mg daily, often as part of a B-complex. Higher therapeutic doses (up to 100-200 mg daily) may be used under medical supervision.
Suggested range
1.3-100 mg daily

Potential benefits

Benefits linked to this supplement form:

Cognitive Function

Research strength: Moderate

 Mood Regulation

Research strength: Moderate

 PMS Relief

Research strength: Strong

 Protein & Amino Acid Metabolism

Research strength: Very strong

 Neurotransmitter Synthesis

Research strength: Strong

 Homocysteine Metabolism

Research strength: Strong

 Hemoglobin Production

Research strength: Strong

 Glycogen Breakdown

Research strength: Strong

Things to watch for

Possible side effects linked to this form:

Neuropathy

How serious: Severe

 Gastrointestinal Discomfort

How serious: low

 Neuropathy (High Dose)

How serious: high

 Photosensitivity

How serious: low

Health goals

Needs and goals this form may help with:

Other forms of Vitamin B6

Compare absorption and active amounts with sibling forms:

Pyridoxal 5'-Phosphate (PLP)

Active form of Vitamin B6; essential cofactor for numerous enzymes.
Vitamin B6 (pyridoxal)

Essential B-vitamin; active coenzyme form; supports protein metabolism, cognitiv...
Vitamin B6 (pyridoxine 5-phosphate)

Active coenzyme form of Vitamin B6; does not require liver activation.
Vitamin B6 (pyridoxine hydrochloride)

Essential vitamin for metabolism, nerve function, and red blood cell formation.
Vitamin B6 (pyridoxine)

Essential vitamin for metabolism, nerve function, and red blood cell formation.
Compare all forms in the table
Technical details â–¼

Chemical ID (CAS)

54-47-7

Formula

C8H10NO6P

Physical properties

Typically a yellowish crystalline powder. Soluble in water. Sensitive to light and heat. Stable under acidic conditions, less stable under neutral or alkaline conditions.

How it’s made

Primarily produced synthetically via chemical phosphorylation of pyridoxal or through microbial fermentation processes using genetically modified microorganisms.