L-Alanyl-L-Glutamine

L-Glutamine

Stable, bioavailable form of glutamine; supports gut health, muscle recovery, and immune function.

Part of L-Glutamine amino acid
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Typical dose

Typical supplemental doses range from 1-10 grams...

Oral Oral safety: very low

About this supplement

L-Alanyl-L-Glutamine is a stable, highly bioavailable dipeptide composed of the amino acids L-alanine and L-glutamine linked by a peptide bond. It serves as an efficient delivery system for glutamine, which is conditionally essential during metabolic stress, trauma, or intense exercise. Unlike free glutamine, which is unstable in solution and prone to degradation, this dipeptide form offers superior stability, solubility, and absorption in the gastrointestinal tract. It is hydrolyzed in the bloodstream and tissues to release its constituent amino acids. Primarily used in clinical nutrition, sports supplements, and gut health formulations, it supports protein synthesis, immune function, intestinal barrier integrity, and cellular hydration.

How much to take

Typical amount
Typical supplemental doses range from 1-10 grams per day, often divided. In clinical nutrition, it is incorporated into parenteral or enteral formulas at specified concentrations.
Suggested range
2-5 g daily for general supplementation; up to 10-20 g daily in clinical or high-stress athletic contexts under professional guidance.

Potential benefits

Benefits linked to this supplement form:

Gut Health

Research strength: Strong

 Recovery

Research strength: Early

 Immune System Support

Research strength: Moderate

 Gut Mucosal Integrity Support

Research strength: Strong

 Muscle Recovery & Protein Synthesis

Research strength: Strong

 Nitrogen Transport & Acid-Base Balance

Research strength: Very strong

 Gut Barrier Support & Integrity

Research strength: Strong

 Improved Glutamine Delivery

Research strength: Very strong

Things to watch for

Possible side effects linked to this form:

None

How serious: None

 Gastrointestinal Discomfort

How serious: low

 Potential Risk in Certain Medical Conditions

How serious: medium

 Potential for Nitrogen Load

How serious: medium

Health goals

Needs and goals this form may help with:

Other forms of L-Glutamine

Compare absorption and active amounts with sibling forms:

Free-form L-Glutamine Powder

Conditionally essential amino acid important for gut and immune health.
N-Acetyl-L-Glutamine

Enhanced stability & bioavailability form of glutamine.
Compare all forms in the table
Technical details â–¼

Chemical ID (CAS)

39537-23-0

Formula

C8H15N3O4

Physical properties

White to off-white crystalline powder. Highly soluble in water. Stable in aqueous solution and during heat processing (unlike free glutamine). Hygroscopic.

How it’s made

Produced synthetically via enzymatic or chemical peptide synthesis, typically coupling N-protected L-alanine with L-glutamine or its derivative, followed by deprotection and purification. Fermentative production using engineered microorganisms is also possible.