Typical dose
500-3000 mg daily, often divided into 2-3 doses....
Oral
Oral safety: very low
About this supplement
N-Acetyl-L-Glutamine is a modified, acetylated form of the amino acid L-glutamine. This chemical modification enhances its stability and bioavailability compared to free glutamine, as it is more resistant to degradation in the digestive tract and plasma. It serves as a more efficient precursor for raising plasma and tissue levels of glutamine, a conditionally essential amino acid critical for protein synthesis, immune function, gut health, and cellular energy production. The acetyl group is cleaved in the body, releasing L-glutamine. It is particularly valued in supplements for its superior absorption and reduced gastrointestinal side effects.
How much to take
- Typical amount
- 500-3000 mg daily, often divided into 2-3 doses. Frequently used in combination with other amino acids or nutrients.
- Suggested range
- 500-3000 mg daily
Potential benefits
Benefits linked to this supplement form:
Things to watch for
Possible side effects linked to this form:
Health goals
Needs and goals this form may help with:
Other forms of L-Glutamine
Compare absorption and active amounts with sibling forms:
Technical details â–¼
Chemical ID (CAS)
2490-97-3
Formula
C7H12N2O4
Physical properties
Typically a white to off-white crystalline powder. Soluble in water. Hygroscopic (absorbs moisture from air).
How it’s made
Produced synthetically via acetylation of L-glutamine. This typically involves reacting L-glutamine with acetic anhydride or acetyl chloride under controlled conditions, followed by purification processes like crystallization.