Trans-resveratrol (standardized extract)

Resveratrol

Standardized for consistent trans-resveratrol content. Potent antioxidant supporting cellular health and longevity pathways.

Part of Resveratrol botanical
Compare all forms

Typical dose

100-500 mg daily, often divided into 2-3 doses....

Oral Oral safety: very low

About this supplement

Trans-resveratrol is a specific stereoisomer of resveratrol, a naturally occurring polyphenolic stilbene compound. As a standardized extract, it contains a consistent, quantified percentage of trans-resveratrol, typically ranging from 50% to 98% purity. This form is the biologically active isomer known for its potent antioxidant, anti-inflammatory, and sirtuin-activating properties. It is extensively researched for its potential effects on longevity pathways, cardiovascular health, neuroprotection, and metabolic regulation. The 'trans-' configuration is more stable and bioactive than its cis-isomer counterpart, especially in standardized extracts that ensure reliable potency for dietary supplement and research applications.

How much to take

Typical amount
100-500 mg daily, often divided into 2-3 doses. Higher doses (1-2 g daily) have been used in clinical studies.
Suggested range
100-1000 mg daily

Potential benefits

Benefits linked to this supplement form:

Antioxidant Support

Research strength: Moderate

 Cardiovascular Health

Research strength: Moderate

 Antioxidant Protection

Research strength: Strong

 Neuroprotection

Research strength: Moderate

 Cardiovascular Support

Research strength: Moderate

 Skin Health & Anti-Aging (Topical)

Research strength: Moderate

 Cellular Longevity Pathways

Research strength: Moderate

 Cellular Longevity Pathway Activation

Research strength: Moderate

 Anti-inflammatory Effects

Research strength: Strong

Things to watch for

Possible side effects linked to this form:

Digestive Issues

How serious: Mild

 Gastrointestinal Discomfort

How serious: low

 Potential Drug Interactions

How serious: medium

 Estrogenic Activity

How serious: low

Health goals

Needs and goals this form may help with:

Other forms of Resveratrol

Compare absorption and active amounts with sibling forms:

Micronized or emulsified resveratrol

Enhanced bioavailability form of resveratrol
Polygonum cuspidatum (Japanese knotweed) extract

Standardized for resveratrol content (typically 20-50% or higher). Used for anti...
Resveratrol analog
Resveratrol analog (unspecified)
Resveratrol analogue
Resveratrol complex (with piperine, quercetin, etc.)

Enhanced absorption formula. Supports cellular health and antioxidant defense.
Resveratrol conjugates
Resveratrol conjugates (mixed)
trans-resveratrol
Compare all forms in the table
Technical details â–¼

Chemical ID (CAS)

501-36-0

Formula

C14H12O3

Physical properties

White to pale yellow crystalline powder. Poor solubility in water; soluble in organic solvents like ethanol, DMSO, and lipids. Melting point approximately 256-258°C. Sensitive to light, heat, and pH changes, which can cause isomerization to the cis-form.

How it’s made

Typically extracted from Polygonum cuspidatum (Japanese knotweed) root, grape skins, or red wine byproducts using solvent extraction (e.g., ethanol). The extract is then purified and standardized via chromatography or crystallization to achieve a high percentage of trans-resveratrol. Some commercial production uses biotechnological methods (fermentation, plant cell culture) or chemical synthesis followed by purification.