Typical dose
Oral: 100-500 mg of standardized extract (typica...
Oral
Oral safety: very low
About this supplement
Polygonum cuspidatum extract is derived from the root of Japanese knotweed, a perennial plant native to East Asia. It is primarily standardized for its high content of resveratrol (a stilbenoid polyphenol), along with other bioactive compounds including emodin, polydatin (resveratrol glucoside), and anthraquinones. The extract is widely used in dietary supplements for its antioxidant, anti-inflammatory, and potential cardioprotective properties. In topical applications, it is valued for skin anti-aging, brightening, and photoprotection due to its ability to inhibit collagen degradation and reduce hyperpigmentation.
How much to take
- Typical amount
- Oral: 100-500 mg of standardized extract (typically providing 20-100 mg resveratrol) daily, often divided. Topical: Formulations typically contain 0.1-1% resveratrol from the extract.
- Suggested range
- Oral: 200-1000 mg of extract daily. Topical: 0.1-1% concentration in final product.
Potential benefits
Benefits linked to this supplement form:
Things to watch for
Possible side effects linked to this form:
Health goals
Needs and goals this form may help with:
Other forms of Resveratrol
Compare absorption and active amounts with sibling forms:
Micronized or emulsified resveratrol
Enhanced bioavailability form of resveratrol
Resveratrol analog
Resveratrol analog (unspecified)
Resveratrol analogue
Resveratrol complex (with piperine, quercetin, etc.)
Enhanced absorption formula. Supports cellular health and antioxidant defense.
Resveratrol conjugates
Resveratrol conjugates (mixed)
trans-resveratrol
Trans-resveratrol (standardized extract)
Standardized for consistent trans-resveratrol content. Potent antioxidant suppor...
Technical details â–¼
Chemical ID (CAS)
84744-66-7 (for extract); 501-36-0 (for resveratrol)
Physical properties
Typically a brown to reddish-brown powder. Soluble in ethanol, glycerin, and water (depending on formulation). Hygroscopic. Characteristic mild herbal odor.
How it’s made
Produced by harvesting the dried rhizomes and roots of Polygonum cuspidatum. The plant material is cleaned, dried, and milled. Bioactive compounds are extracted using solvents such as ethanol, water, or supercritical CO2. The extract is then concentrated, purified, and often standardized to a specific resveratrol or polydatin content via chromatographic methods.