Part of
Saccharomyces
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Typical dose
Typically 250-500 mg (providing 3-10 billion CFU...
About this supplement
Saccharomyces boulardii CNCM I-745 is a specific, well-researched strain of probiotic yeast originally isolated from lychee and mangosteen fruit in Southeast Asia. It is a non-pathogenic, thermophilic yeast that survives gastric acidity and transiently colonizes the gastrointestinal tract without permanently altering the gut microbiota. This strain is distinct from brewer's or baker's yeast (Saccharomyces cerevisiae) and is clinically documented for its ability to support gastrointestinal health, particularly in managing various forms of diarrhea and maintaining gut barrier function. The designation 'CNCM I-745' indicates it is deposited in the French National Collection of Microorganism Cultures (Collection Nationale de Cultures de Microorganismes).
How much to take
- Typical amount
- Typically 250-500 mg (providing 3-10 billion CFUs) taken 1-2 times daily, often during or after meals.
- Suggested range
- 250-1000 mg daily (providing 3-20 billion CFUs daily)
Potential benefits
Benefits linked to this supplement form:
Prevention of Antibiotic-Associated Diarrhea
Research strength: Very strong
Treatment of Acute Infectious DiarrheaResearch strength: Strong
Support during H. pylori Eradication TherapyResearch strength: Strong
Gut Barrier Function SupportResearch strength: Strong
Management of Traveler's DiarrheaResearch strength: Moderate
Things to watch for
Possible side effects linked to this form:
Health goals
Needs and goals this form may help with:
Other forms of Saccharomyces
Compare absorption and active amounts with sibling forms:
Lyophilized (freeze-dried) S. boulardii
Probiotic yeast; supports digestive health; helps maintain gut flora balance dur...
Saccharomyces
Saccharomyces (unspecified)
Saccharomyces boulardii
Saccharomyces boulardii
Saccharomyces boulardii DBVPG 6763
Probiotic yeast for digestive support. Use during antibiotic therapy. Not for im...
Saccharomyces boulardii lyo
Saccharomyces boullardii
Saccharomyces cerevisae
Saccharomyces cerevisiae
Saccharomyces cerevisiae
Saccharomyces cerevisiae peptides
Saccharomyces exiguus
Saccharomyces turicensis
Saccharomyces unisporus
Technical details â–¼
Physical properties
Typically supplied as a lyophilized (freeze-dried) powder, off-white to beige in color. The viable yeast cells are oval-shaped, approximately 5-7 micrometers in diameter. Soluble in water when reconstituted. Requires protection from moisture and heat to maintain viability.
How it’s made
Produced via controlled fermentation in a nutrient-rich medium under aerobic conditions. The yeast biomass is harvested, washed, concentrated, and then lyophilized (freeze-dried) to preserve viability. The final product is blended with excipients (like maltodextrin) for stability and standardized to a guaranteed colony-forming unit (CFU) count per dose.