Typical dose
300-1200 mg daily, often divided into 2-3 doses.
Oral
Oral safety: very low
About this supplement
Choline alfoscerate, also known as Alpha-GPC (L-alpha-glycerylphosphorylcholine), is a highly bioavailable choline compound that serves as a precursor to the neurotransmitter acetylcholine and to membrane phospholipids. It is a natural choline compound found in the brain and in some foods, but is typically produced synthetically for supplementation. This specific form is the alfoscerate salt of choline, which enhances stability and bioavailability. It readily crosses the blood-brain barrier and is involved in cognitive function, neurotransmission, and cell membrane integrity. It is classified as a nootropic and cholinergic agent.
How much to take
- Typical amount
- 300-1200 mg daily, often divided into 2-3 doses.
- Suggested range
- 300-1200 mg daily
Potential benefits
Benefits linked to this supplement form:
Cognitive Function
Research strength: Strong
Power OutputResearch strength: Moderate
Cognitive SupportResearch strength: Strong
NeuroprotectionResearch strength: Moderate
Cognitive Enhancement & Memory SupportResearch strength: Strong
Neurological Recovery SupportResearch strength: Strong
Growth Hormone ReleaseResearch strength: Moderate
Athletic PerformanceResearch strength: Moderate
Choline RepletionResearch strength: Strong
Things to watch for
Possible side effects linked to this form:
Health goals
Needs and goals this form may help with:
- Sustained Focus & Concentration Cognition
- Memory & Recall Cognition
- Mental Energy & Brain Fog Cognition
- Cooling & Sensory Clarity (Topical) Cognition
- Daytime Energy & Stamina Recovery
- Fatigue & Low Energy Recovery
- Muscle Building & Strength Recovery
- Exercise Recovery & Muscle Soreness Recovery
- Joint Mobility & Stiffness Recovery
- Joint Comfort After Activity Recovery
- Topical Muscle & Joint Comfort Recovery
- Blood Pressure Wellness Longevity
- Circulation & Vascular Comfort Longevity
- Bone Density & Strength Longevity
- Healthy Aging & Cellular Vitality Longevity
- Sun Protection & Photoaging Care Longevity
- Age-Related Cognitive Decline
- Enhanced Mental Performance
- Choline Deficiency
Other forms of Alpha-GPC
Compare absorption and active amounts with sibling forms:
Technical details â–¼
Chemical ID (CAS)
28319-77-9
Formula
C8H20NO6P
Physical properties
Typically a white or off-white crystalline powder. Hygroscopic (absorbs moisture from air). Soluble in water. Often stabilized as a salt (alfoscerate) for supplement use.
How it’s made
Primarily produced synthetically via chemical synthesis from phosphatidylcholine (often derived from soy lecithin) through enzymatic or chemical deacylation and purification processes. The alfoscerate salt form is created for enhanced stability.