Amino Acids Amino Acids Oral

5-HTP

5-HTP is a serotonin precursor used for mood enhancement and sleep support.

Sci.5-Hydroxytryptophan 5-HTP (5-Hydroxytryptophan)
1 form
Oral

About 5-HTP

5-Hydroxytryptophan (5-HTP) is an amino acid that serves as a precursor to serotonin, a neurotransmitter that plays a crucial role in regulating mood, sleep, and appetite. It is commonly used as a dietary supplement for mood support and to aid sleep quality.

Official resources

Fact sheets from the NIH Office of Dietary Supplements related to this ingredient group.

At a glance

Approval status

supplement

Compare All Forms

1 form

Compare supplement forms of 5-HTP by absorption quality and what your body actually gets from each:

High Moderate Low
Form Absorption Steps to absorb Notes Action
5-HTP (5-Hydroxytryptophan)
  • CAS: 4350-09-8
  • Label category: Natural (Griffonia simplicifolia seed)
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Type: Amino Acids

Building blocks of proteins. Essential amino acids must be obtained from diet, while non-essential can be synthesized by the body.

Absorption: Amino acids are generally well-absorbed. Some forms (like citrulline) are more effective than others (like arginine).

Interactions: Generally safe but high doses can cause digestive issues. Some amino acids can affect neurotransmitter levels.

Watch out for

Possible interactions or cautions — talk to a healthcare provider if unsure.

  • May interact with antidepressants, particularly SSRIs and MAOIs, leading to serotonin syndrome.

Potential Benefits

Benefits associated with 5-HTP forms:

Sleep Quality Mood Support Sleep aid

Potential Side Effects

Side effects associated with 5-HTP forms:

Drowsiness How serious: Mild Nausea How serious: Mild Serotonin Syndrome (with SSRIs) How serious: Severe Gastrointestinal issues How serious: medium

What does the research say?

Numerous studies have investigated the effects of 5-HTP on mood and sleep. Research indicates that 5-HTP supplementation may lead to improvements in mood and reductions in symptoms of depression. Additionally, some studies suggest that it may enhance sleep quality by increasing serotonin levels, which are linked to sleep regulation.