Serotonin Syndrome (with SSRIs)

Serotonin syndrome is a potentially life-threatening condition resulting from excessive serotonin activity, often caused by combining SSRIs with other serotonergic drugs. Symptoms range from tremor to coma, requiring immediate medical attention in severe cases.

Serotonin syndrome is a potentially life-threatening condition caused by excessive serotonin activity in the central nervous system. It most commonly occurs when Selective Serotonin Reuptake Inhibitors (SSRIs) are combined with other serotonergic agents, such as MAOIs, tricyclic antidepressants, certain pain medications (tramadol, fentanyl), St. John's Wort, or illicit drugs like MDMA. Symptoms can range from mild (tremor, diarrhea) to severe (muscle rigidity, hyperthermia, seizures, coma). Diagnosis is primarily clinical, based on a detailed medication history and physical examination. Mild cases may resolve with discontinuation of the offending agents, while severe cases require hospitalization and supportive care, including serotonin antagonists like cyproheptadine.