Glutathione is a key antioxidant and detoxifier that protects cells and supports immune function but needs cautious supplementation.
Glutathione is a tripeptide naturally produced in the body and available as a supplement. It is a potent antioxidant involved in detoxification, immune function, and cellular protection. Supplementation can take various forms (oral, intravenous, topical). While generally considered safe, potential side effects like gastrointestinal issues, allergic reactions, and possible zinc deficiency exist. Dosage varies, and consulting a healthcare professional before supplementation, especially with high doses or prolonged use, is recommended. Research supports its antioxidant and detoxification roles; however, efficacy claims for other benefits, like skin brightening, need more investigation.
Key Information
Inside Body Harmful Score
Common Dosage
250-500mg daily, although dosages can vary widely depending on the form and purpose.
Source Type
natural
Production Process
Glutathione is produced naturally within the body from three amino acids: cysteine, glutamic acid, and glycine. Supplementally, it can be produced through microbial fermentation or chemical synthesis.
Use Type
Inside BodyPotential Benefits
Antioxidant support protects cells from damage by neutralizing free radicals, supporting immune function, and reducing inflammation. It contributes to overall health and may reduce the risk of chronic diseases.
This benefit aims to improve overall skin health and appearance through increased hydration, reduced inflammation, improved elasticity, and protection from environmental damage. Healthy skin exhibits a smooth texture, even tone, and strong barrier function.
Detoxification describes the body's natural process of eliminating toxins via organs like the liver and kidneys. Commercial 'detox' products claim to support these processes, but evidence is often limited.
Antioxidant protection defends the body against free radical damage, reducing the risk of chronic diseases and promoting overall cellular health. This is achieved by neutralizing unstable molecules that cause oxidative stress and cellular damage.
Neuroprotection aims to protect the brain and nervous system from damage and degeneration by preventing neuronal cell death, reducing inflammation, and enhancing synaptic plasticity. Strategies include lifestyle modifications, nutritional supplementation, and pharmacological interventions to mitigate effects of aging, neurodegenerative diseases, stroke, and traumatic brain injury.
Zinc supports the immune system by enhancing immune cell activity, reducing infection risk, and modulating inflammatory responses. Supplementation is particularly beneficial for individuals with zinc deficiencies, helping to restore optimal zinc levels and bolster immune response.
Skin brightening aims to lighten skin tone and reduce hyperpigmentation through melanin inhibition, exfoliation, and protection against UV damage. This results in a more even and radiant complexion.
S-Acetyl Glutathione may support detoxification by increasing glutathione levels, which is crucial for the liver's ability to process and eliminate toxins and free radicals.
Glutathione inhibits melanin production, leading to a lighter skin tone, reduced hyperpigmentation, and improved skin radiance. Effectiveness varies based on product, concentration, and individual skin.
Possible Side Effects
Allergic reactions are hypersensitivity responses to allergens, ranging from mild skin irritation to life-threatening anaphylaxis. Symptoms vary widely and are caused by an immune response.
Gastrointestinal issues include nausea, diarrhea, abdominal discomfort, and vomiting, potentially stemming from altered gut motility, microbiota changes, or irritation. While often mild, persistent symptoms necessitate evaluation, and contributing factors like pre-existing conditions should be considered.
Glutathione, especially at high doses, can inhibit zinc absorption, potentially leading to a zinc deficiency. Monitoring is advised during long-term, high-dose supplementation.
Scientific Evidence
Numerous studies on glutathione's antioxidant properties (e.g., 'Oxidative Medicine and Cellular Longevity'), detoxification mechanisms (e.g., studies on glutathione S-transferases), and immune-modulating effects. Clinical trials examining its use in specific conditions like liver disease and neurodegenerative disorders are also relevant.
User Reviews
Share your experience with this ingredient
Log in to write a reviewNo reviews yet. Be the first to share your experience!