Typical dose
40-1000 mg daily, often taken in a single dose....
Oral & topical
Oral safety: harmless
Skin safety: harmless
About this supplement
Type II Collagen Peptides (Hydrolyzed) are short-chain peptides derived from the enzymatic hydrolysis of native Type II collagen, primarily sourced from chicken sternal cartilage or bovine trachea. Type II collagen is the main structural protein in articular cartilage and hyaline cartilage. Hydrolysis breaks down the large collagen molecules into smaller, more bioavailable peptides that are soluble in cold water and easily absorbed when taken orally. This specific form targets joint health by potentially modulating immune responses to collagen in joints and providing building blocks for cartilage matrix synthesis. Unlike generic collagen peptides (often Types I and III from skin/bone), Type II peptides are specifically associated with cartilage structure and joint comfort.
How much to take
- Typical amount
- 40-1000 mg daily, often taken in a single dose. Many studies use doses around 40 mg (for undenatured) to 1000-2000 mg (for hydrolyzed forms).
- Suggested range
- 40-2000 mg daily
Potential benefits
Benefits linked to this supplement form:
Things to watch for
Possible side effects linked to this form:
Health goals
Needs and goals this form may help with:
Other forms of Collagen
Compare absorption and active amounts with sibling forms:
Chicken Collagen (Type II)
Targeted joint support from chicken cartilage; often labeled as UC-II for undena...
Collagen
Collagen (mixed)
collagen (unknown source)
Collagen (unspecified)
Collagen Hydrolysate
Hydrolyzed for improved solubility and absorption.
Collagen II
Collagen Peptides
Hydrolyzed Chicken Collagen
Hydrolyzed Marine Collagen
Marine Collagen
Marine Collagen Peptides
Derived from fish; supports skin, joint, and bone health
Peptan (Collagen Peptides)
Hydrolyzed collagen peptides for joint, skin, and bone support.
Undenatured Type II Collagen
Verisol (Bioactive Collagen Peptides)
Clinically studied bioactive collagen peptides for skin, hair, and nail support.
Technical details â–¼
Chemical ID (CAS)
9064-67-9 (for collagen, hydrolysates)
Physical properties
Typically a fine, off-white to light yellow powder. Hygroscopic. Soluble in cold water, forming a clear or slightly opalescent solution. Insoluble in organic solvents. Derived via enzymatic hydrolysis, resulting in low molecular weight peptides (typically 2-10 kDa).
How it’s made
Produced by cleaning and processing cartilage-rich tissues (e.g., chicken sternum). Native Type II collagen is extracted and then subjected to controlled enzymatic hydrolysis (using proteases like pepsin, trypsin, or bacterial enzymes) to break peptide bonds. The hydrolysate is filtered, purified, concentrated, and spray-dried into a powder.