Citrulline Malate (2:1)

L-Citrulline

Supports blood flow, exercise performance, and recovery

Part of L-Citrulline amino acid
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Typical dose

Commonly used in doses of 6-8 grams taken approx...

Oral Oral safety: harmless

About this supplement

Citrulline Malate (2:1) is a specific salt compound formed by combining two molecules of the amino acid L-citrulline with one molecule of malic acid. This 2:1 ratio is the most common and well-researched form in dietary supplements. L-citrulline is a non-essential amino acid involved in the urea cycle, while malic acid is an organic compound found in fruits that plays a role in cellular energy production (Krebs cycle). The combination is believed to enhance the bioavailability and efficacy of citrulline, particularly for exercise performance and vascular function. It is water-soluble, stable, and commonly used in sports nutrition and cardiovascular support formulas.

How much to take

Typical amount
Commonly used in doses of 6-8 grams taken approximately 60 minutes before exercise. For general vascular support, doses of 1-3 grams daily are used.
Suggested range
1000-8000 mg daily

Potential benefits

Benefits linked to this supplement form:

Blood Flow (Pump)

Research strength: Strong

 Exercise Performance

Research strength: Strong

 Blood Pressure

Research strength: Moderate

 Improves Blood Flow & Vasodilation

Research strength: Strong

 Enhances Exercise Performance & Reduces Fatigue

Research strength: Strong

 Supports Cardiovascular Health

Research strength: Moderate

 Supports Erectile Function

Research strength: Moderate

 Supports Vascular Health & Blood Flow

Research strength: Strong

 Accelerates Muscle Recovery

Research strength: Moderate

Things to watch for

Possible side effects linked to this form:

Gastrointestinal Upset

How serious: Mild

 Headache

How serious: Mild

 Gastrointestinal Discomfort

How serious: low

 Low Blood Pressure (Hypotension)

How serious: medium

Health goals

Needs and goals this form may help with:

Other forms of L-Citrulline

Compare absorption and active amounts with sibling forms:

L-Citrulline DL-Malate
Compare all forms in the table
Technical details â–¼

Chemical ID (CAS)

54940-97-5

Formula

C6H13N3O3 • C4H6O5 (2:1 salt)

Physical properties

Typically a white to off-white crystalline powder. Highly soluble in water. Stable at room temperature when kept dry.

How it’s made

Produced synthetically via chemical synthesis or fermentation. L-citrulline (produced via fermentation of sugars by microorganisms or via chemical synthesis from ornithine) is combined with malic acid (typically produced via petrochemical processes or fermentation) in a controlled 2:1 molar ratio to form the salt. The mixture is then purified, crystallized, and dried.