Casein Phosphopeptides

Peptides

Mineral-binding peptide from milk; supports dental health and mineral absorption

Part of Peptides amino acid
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Typical dose

For dental applications (topical): 1-2% in tooth...

Oral & topical Oral safety: very low Skin safety: harmless

About this supplement

Casein phosphopeptides (CPPs) are bioactive peptides derived from the enzymatic hydrolysis of casein, the main protein in milk. They are characterized by clusters of phosphorylated serine residues that give them unique mineral-binding properties, particularly for calcium and other divalent cations. CPPs are known for their ability to form soluble complexes with calcium, enhancing its bioavailability and preventing precipitation in the intestinal tract. They are extensively studied for dental applications due to their role in remineralizing tooth enamel and preventing dental caries by stabilizing amorphous calcium phosphate at the tooth surface. In nutritional supplements, they are used to improve mineral absorption and bone health.

How much to take

Typical amount
For dental applications (topical): 1-2% in toothpaste or chewing gum. For oral supplementation: 100-500 mg daily, often combined with calcium.
Suggested range
100-500 mg daily

Potential benefits

Benefits linked to this supplement form:

Dental Enamel Remineralization

Research strength: Strong

 Enhanced Mineral Absorption

Research strength: Moderate

 Caries Prevention

Research strength: Strong

Things to watch for

Possible side effects linked to this form:

Allergic Reaction

How serious: Moderate

 Gastrointestinal Discomfort

How serious: low

Health goals

Needs and goals this form may help with:

Other forms of Peptides

Compare absorption and active amounts with sibling forms:

Collagen Hydrolysate (Hydrolyzed Collagen Peptides)

Hydrolyzed for enhanced absorption. Supports skin, hair, nails, and joints.
Copper Tripeptide-1 (GHK-Cu)

Supports skin repair, collagen production, and hair growth.
Palmitoyl Pentapeptide-4 (Matrixyl)

A topically applied peptide for reducing signs of skin aging.
Peptides

Broad term for short amino acid chains; function varies by specific sequence.
Peptides (unspecified)

Broad category; specific peptide identity required for precise benefits.
Peptides (unspecified)

Broad-spectrum peptide blend; source and sequence not specified.
Whey Protein Hydrolysate

Fast-absorbing protein; may reduce digestive discomfort; often used in 'hydrolyz...
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Technical details â–¼

Physical properties

Typically a white to off-white powder. Soluble in water. Hydrophilic due to phosphorylated serine clusters. Often complexed with amorphous calcium phosphate (ACP) in dental products.

How it’s made

Produced by enzymatic hydrolysis (typically using trypsin) of casein, followed by purification steps such as ultrafiltration and ion-exchange chromatography to isolate the phosphorylated peptide fractions.