Palmitoyl Pentapeptide-4 (Matrixyl)

Peptides

A topically applied peptide for reducing signs of skin aging.

Part of Peptides amino acid
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Typical dose

Apply topically in formulations (e.g., serums, c...

Oral & topical Oral safety: very low Skin safety: harmless

About this supplement

Palmitoyl Pentapeptide-4, commercially known as Matrixyl, is a synthetic lipopeptide consisting of five amino acids (Lysine-Threonine-Threonine-Lysine-Serine) conjugated to a palmitoyl fatty acid chain. This modification enhances skin penetration and stability. It is a well-researched cosmetic peptide that mimics the N-terminal fragment of type I procollagen, specifically the sequence of the C-propeptide of collagen α1(I). It functions as a signal peptide in skin tissue, stimulating collagen I, III, and IV synthesis, fibronectin production, and inhibiting collagen-degrading enzymes (matrix metalloproteinases). It is primarily used in anti-aging skincare formulations to reduce the appearance of fine lines and wrinkles and improve skin firmness.

How much to take

Typical amount
Apply topically in formulations (e.g., serums, creams) typically containing 2-10 ppm (parts per million) of the peptide.
Suggested range
2-10 ppm in final topical formulation

Potential benefits

Benefits linked to this supplement form:

Reduces Wrinkles and Fine Lines

Research strength: Strong

 Improves Skin Firmness and Elasticity

Research strength: Strong

 Improves Skin Smoothness and Texture

Research strength: Moderate

Things to watch for

Possible side effects linked to this form:

Skin Irritation

How serious: Mild

Health goals

Needs and goals this form may help with:

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Broad term for short amino acid chains; function varies by specific sequence.
Peptides (unspecified)

Broad category; specific peptide identity required for precise benefits.
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Broad-spectrum peptide blend; source and sequence not specified.
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Technical details â–¼

Chemical ID (CAS)

214047-00-4

Physical properties

Typically a white to off-white powder. Soluble in water and aqueous solutions. The palmitoyl chain confers lipophilic properties, aiding skin penetration.

How it’s made

Produced via solid-phase peptide synthesis (SPPS), where the pentapeptide sequence (KTTKS) is assembled stepwise on a resin. The N-terminal lysine is then acylated with palmitic acid. The final product is cleaved from the resin, purified, and lyophilized.