Typical dose
For neonatal apnea: Loading dose of 20 mg/kg, fo...
Oral
Oral safety: low
About this supplement
Caffeine citrate is a chemical complex formed by combining caffeine with citric acid. This formulation is primarily used in medical settings, particularly for the treatment of apnea of prematurity in newborn infants. It acts as a central nervous system and respiratory stimulant. The citrate salt form enhances the water solubility of caffeine, making it more suitable for precise intravenous or oral administration in clinical environments. While caffeine itself is a well-known stimulant found in coffee, tea, and energy drinks, caffeine citrate is a specific pharmaceutical preparation with standardized dosing.
How much to take
- Typical amount
- For neonatal apnea: Loading dose of 20 mg/kg, followed by maintenance dose of 5-10 mg/kg daily, as directed by a physician. In adult dietary supplements, caffeine content is typically much lower and based on the caffeine moiety (e.g., 100-200mg).
- Suggested range
- 5-10 mg/kg/day (for medical use in infants). Adult supplement use should follow general caffeine guidelines of up to 400mg caffeine per day.
Potential benefits
Benefits linked to this supplement form:
Things to watch for
Possible side effects linked to this form:
Health goals
Needs and goals this form may help with:
Other forms of Caffeine
Compare absorption and active amounts with sibling forms:
Caffeine alpha-ketoglutarate
Caffeine Anhydrous
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Caffeine pterostilbene
Dicaffeine Malate
Often marketed for sustained energy and focus with reduced side effects.
Natural Caffeine (from Coffea/Guarana)
Natural stimulant from coffee beans or guarana. May improve alertness and exerci...
Sustained/Extended-Release Caffeine
Provides prolonged energy and focus; may reduce jitters and crash compared to st...
Technical details â–¼
Chemical ID (CAS)
69-22-7
Formula
C8H10N4O2 · C6H8O7
Physical properties
Typically appears as a white, crystalline powder. Highly soluble in water due to the citrate salt formation. Odorless with a bitter taste.
How it’s made
Produced synthetically by reacting caffeine base with citric acid in a controlled chemical process, followed by purification and crystallization to achieve pharmaceutical grade.