synthetic additive Synthetic Additive Oral

Advantame

An ultra-high-potency artificial sweetener derived from aspartame, used as a sugar substitute in foods and beverages.

Sci.N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester E 969
1 form
Oral

About Advantame

Advantame is a high-intensity, non-nutritive artificial sweetener derived from aspartame and vanillin. It is a dipeptide methyl ester derivative, approximately 20,000 times sweeter than sucrose and 100 times sweeter than aspartame. As a member of the dipeptide-derived sweetener family, it is metabolized into its constituent amino acids (aspartic acid and phenylalanine) and methanol, but due to its extreme potency, the quantities ingested are negligible. It is heat-stable and used as a tabletop sweetener and in a wide variety of processed foods and beverages.

Official resources

Fact sheets from the NIH Office of Dietary Supplements related to this ingredient group.

At a glance

Max safe daily

The FDA established an Acceptable Daily Intake (ADI) of 32.8 mg per kg of body weight per day. The EFSA set an ADI of 5 mg per kg of body weight per day.

Approval status

GRAS (FDA), approved food additive in the EU, Australia, and other jurisdictions.

Compare All Forms

1 form

Compare supplement forms of Advantame by absorption quality and what your body actually gets from each:

High Moderate Low
Form Absorption Steps to absorb Notes Action
Advantame

High-intensity sweetener for reduced-calorie foods and bever...

  • UNII: VJ597D52EX
  • CAS: 714229-20-6
  • Label category: synthetic
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Also appears on labels as

Additional names seen on supplement labels for forms of this ingredient (beyond the main aliases above).

Advantame

Type: Synthetic Additive

Category for Synthetic Additive ingredients

Watch out for

Possible interactions or cautions — talk to a healthcare provider if unsure.

  • Contains phenylalanine; contraindicated for individuals with phenylketonuria (PKU).

Potential Benefits

Benefits associated with Advantame forms:

Dental Health Calorie Reduction Blood sugar management Heat Stability

Potential Side Effects

Side effects associated with Advantame forms:

Gastrointestinal Discomfort How serious: low Phenylketonuria (PKU) Concern How serious: low

What does the research say?

Approved as safe for human consumption by major regulatory agencies based on extensive toxicological studies. The FDA's approval in 2014 and EFSA's positive opinion in 2013 were based on reviews of data from over 37 animal and human studies, which found no evidence of carcinogenicity, genotoxicity, or reproductive toxicity at estimated intake levels. It is not metabolized for energy and is excreted largely unchanged.