Neurotoxicity (excessive)

Excessive neurotoxicity involves damage to the nervous system from chemical, physical, or biological agents, leading to cognitive, motor, sensory, psychiatric, and autonomic dysfunction. It can result in permanent neurological damage or death in severe cases.

Excessive neurotoxicity refers to damage or dysfunction of the central or peripheral nervous system caused by exposure to chemical, physical, or biological agents. This can manifest in a variety of symptoms, including cognitive impairment (memory loss, confusion), motor deficits (tremors, seizures, weakness, paralysis), sensory disturbances (numbness, tingling, vision changes), psychiatric symptoms (depression, anxiety, psychosis), and autonomic dysfunction (changes in heart rate, blood pressure, breathing). The severity and specific symptoms depend on the agent involved, the dose, the duration of exposure, and individual susceptibility. In excessive cases, neurotoxicity can lead to permanent neurological damage or death. The underlying mechanisms can include oxidative stress, excitotoxicity, mitochondrial dysfunction, inflammation, disruption of the blood-brain barrier, and interference with neurotransmitter signaling. Diagnosis often involves neurological examination, neuroimaging (MRI, CT scan), electrophysiological studies (EEG, nerve conduction studies), and laboratory tests to identify the causative agent.