Urolithin A improves mitochondrial health and promotes mitophagy, depending on gut microbiome composition.
Urolithin A is a metabolite produced by gut bacteria from ellagitannins found in foods like pomegranates, or available as a synthetic supplement. It enhances mitochondrial health by promoting mitophagy, potentially improving muscle function and exhibiting anti-aging properties. While generally safe, mild gastrointestinal side effects are possible. Supplementation bypasses the dependence on gut microbiome composition required for production from dietary precursors.
Key Information
Inside Body Harmful Score
Common Dosage
250-1000mg daily
Source Type
hybrid
Production Process
Produced naturally by gut bacteria metabolizing ellagitannins (found in foods like pomegranates) or synthetically manufactured as a supplement.
Use Type
Inside BodyPotential Benefits
Enhances and maintains the proper functioning of muscles, improving strength, power, endurance, and coordination. Optimal muscle function is crucial for mobility, balance, posture, and reduces risk of injury.
Mitochondrial health enhancement optimizes mitochondrial function to boost cellular energy, reduce fatigue, and support healthy aging. It involves protecting mitochondria, providing essential nutrients, and promoting mitochondrial biogenesis.
Improved gut health involves balancing gut microbiota, optimizing digestion, and reducing gastrointestinal discomfort. This leads to enhanced nutrient absorption, reduced inflammation, regulated bowel movements, and symptom relief.
Urolithin A enhances muscle strength and endurance by improving mitochondrial function within muscle cells, particularly beneficial for older adults. It promotes mitophagy, leading to healthier muscle cells and increased energy production.
Urolithin A promotes mitophagy and improves cellular health, potentially slowing age-related decline in tissues and organs. This is achieved by removing damaged mitochondria and enhancing mitochondrial function.
Rosehip seed oil combats aging by protecting skin from free radicals with antioxidants like vitamin C and E, reducing wrinkles and age spots. Retinoic acid promotes skin cell turnover for a rejuvenated appearance.
Possible Side Effects
Allergic reactions are hypersensitivity responses to allergens, ranging from mild skin irritation to life-threatening anaphylaxis. Symptoms vary widely and are caused by an immune response.
Gastrointestinal discomfort includes nausea, bloating, and diarrhea, typically mild and transient. Symptoms are often dose-dependent and vary in severity.
Scientific Evidence
Available scientific literature including studies on cellular mechanisms, animal models, and human clinical trials investigating effects on mitochondrial function, muscle strength, and biomarkers of aging. Further research is ongoing to fully elucidate its long-term effects and optimal dosage.
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