Sodium hyaluronate is the sodium salt form of hyaluronic acid, a naturally occurring glycosaminoglycan found abundantly in skin, joints, and eyes. It is primarily produced through bacterial fermentati...
Sodium hyaluronate is the sodium salt form of hyaluronic acid, a naturally occurring glycosaminoglycan found abundantly in skin, joints, and eyes. It is primarily produced through bacterial fermentation. Highly prized for its humectant properties, it is widely used in cosmetics, dermatology, and medicine to improve hydration, lubrication, and promote wound healing. Oral use is investigated for supporting joint health. Generally considered safe, topical use can cause mild skin irritation, and oral intake may result in minor gastrointestinal issues. Allergic reactions are rare but require immediate attention. Typical dosages vary between 50-300mg daily based on the application.
Key Information
Outside Body Harmful Score
Common Dosage
50-300mg daily
Source Type
hybrid
Production Process
Primarily produced via bacterial fermentation, often using Streptococcus species, to create hyaluronic acid, which is then converted to its sodium salt form, sodium hyaluronate.
Use Type
Outside BodyPotential Benefits
Skin hydration is essential for maintaining skin elasticity, barrier function, and overall appearance. It reduces fine lines, protects against environmental stressors, and improves skin smoothness and suppleness.
Enhances and maintains optimal eye function and health by supporting clear vision, reducing the risk of age-related eye diseases, and protecting against environmental stressors. Benefits may extend to improved night vision and reduced eye strain.
Accelerates and supports the body's natural wound repair processes. This includes reducing inflammation, promoting collagen synthesis, increasing cell proliferation, and facilitating angiogenesis, leading to faster wound closure, reduced scarring, and decreased infection risk.
Joint lubrication, achieved through hyaluronic acid supplementation or injections, reduces friction in joints, alleviating pain and improving joint function, especially in those with osteoarthritis.
Possible Side Effects
Allergic reactions are hypersensitivity responses to allergens, ranging from mild skin irritation to life-threatening anaphylaxis. Symptoms vary widely and are caused by an immune response.
Allergic reactions are adverse immune responses to normally harmless substances, ranging from mild skin irritation to severe anaphylaxis. Symptoms can include skin issues, swelling, breathing difficulties, and anaphylaxis requires immediate epinephrine injection.
Gastrointestinal discomfort includes nausea, bloating, and diarrhea, typically mild and transient. Symptoms are often dose-dependent and vary in severity.
Hyaluronic acid injections can cause temporary and mild reactions at the injection site such as pain, swelling, redness, and bruising. These effects are usually self-limiting and resolve within a few days.
Topical application can cause mild redness, itching, or burning, especially in individuals with sensitive skin. Symptoms are usually self-limiting but should be monitored.
Oral ingestion may cause mild gastrointestinal issues such as bloating or nausea, usually resolving on their own. Starting with a low dose is advised to reduce the risk.
Scientific Evidence
Key scientific sources and studies include clinical trials evaluating the efficacy of topical sodium hyaluronate for skin hydration, studies assessing the impact of oral sodium hyaluronate on joint pain and function, and research exploring its role in wound healing processes.
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