Nonapeptide-1 is a peptide that reduces hyperpigmentation by blocking the MC1R receptor and inhibiting melanogenesis.
Nonapeptide-1 is a synthetically produced nine-amino acid peptide primarily used in cosmetic formulations for its skin-brightening and anti-hyperpigmentation properties. It functions by competitively binding to the MC1R receptor, inhibiting melanogenesis. It is generally well-tolerated, but mild skin irritation and rare allergic reactions are possible. Research supporting its efficacy is primarily focused on topical applications and demonstrates moderate effectiveness in reducing melanin production and improving skin tone evenness.
Key Information
Outside Body Harmful Score
Common Dosage
Dosage varies depending on the formulation and intended use; typically found in concentrations ranging from 0.001% to 0.1% in cosmetic products.
Source Type
synthetic
Production Process
Nonapeptide-1 is synthesized through chemical peptide synthesis, involving the sequential addition of amino acids to form the desired nine-amino acid chain. Protecting groups are used to ensure the correct peptide sequence and prevent unwanted side reactions.
Use Type
Outside BodyPotential Benefits
Hyperpigmentation reduction lightens or evens out skin tone in areas with excessive melanin production by targeting melanin synthesis, transfer, or removal. Treatments involve topical agents, procedures, and sun protection.
Skin brightening aims to lighten skin tone and reduce hyperpigmentation through melanin inhibition, exfoliation, and protection against UV damage. This results in a more even and radiant complexion.
Nonapeptide-1 reduces melanin production by blocking MSH binding to melanocytes, leading to a skin-brightening or lightening effect. This is achieved through competitive inhibition of the MC1R receptor.
Possible Side Effects
Skin irritation involves symptoms like redness, itching, and rashes due to contact with irritants, allergens, or environmental factors. Severity varies based on the cause, individual sensitivity, and affected area; persistent cases may lead to secondary infections.
Allergic reactions are adverse immune responses to normally harmless substances, ranging from mild skin irritation to severe anaphylaxis. Symptoms can include skin issues, swelling, breathing difficulties, and anaphylaxis requires immediate epinephrine injection.
Scientific Evidence
Limited human studies available; efficacy data mostly derived from in vitro studies and manufacturer-provided data; further research is needed to fully establish the long-term efficacy and safety profile.
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