Skin Brightening/Lightening

Nonapeptide-1 reduces melanin production by blocking MSH binding to melanocytes, leading to a skin-brightening or lightening effect. This is achieved through competitive inhibition of the MC1R receptor.

Nonapeptide-1 acts as a melanogenesis inhibitor by competitively binding to the MC1R receptor on melanocytes, preventing melanocyte-stimulating hormone (MSH) from binding. This competitive inhibition reduces melanin production within melanocytes, resulting in a perceived brightening or lightening of the skin.