Nicotinamide Riboside (NR) is a synthetic form of vitamin B3 and a precursor to NAD+, a critical coenzyme involved in numerous cellular processes including energy production, DNA repair, and overall c...
Nicotinamide Riboside (NR) is a synthetic form of vitamin B3 and a precursor to NAD+, a critical coenzyme involved in numerous cellular processes including energy production, DNA repair, and overall cellular health. Supplementation with NR aims to elevate NAD+ levels, potentially resulting in benefits such as enhanced energy metabolism, anti-aging effects, and neuroprotection. NR is generally considered safe for most individuals, although some may experience mild side effects. While research is ongoing, the potential benefits of NR in promoting healthy aging and preventing age-related diseases are promising. Long-term studies are still needed to fully understand the full spectrum of benefits and potential risks associated with NR supplementation.
Key Information
Inside Body Harmful Score
Common Dosage
100-300mg daily
Source Type
synthetic
Production Process
NR is typically produced through chemical synthesis or enzymatic conversion from other nicotinamide compounds.
Use Type
Inside BodyPotential Benefits
Boosts cellular energy production (ATP) by optimizing mitochondrial function, leading to increased physical and mental energy and reduced fatigue. This improves metabolic efficiency and cellular function across tissues and organs.
Anti-aging interventions protect cells from damage, promote cellular repair, and reduce the risk of age-related diseases. Strategies include dietary interventions, supplementation, lifestyle modifications, and topical treatments to improve overall health and well-being.
Neuroprotection aims to protect the brain and nervous system from damage and degeneration by preventing neuronal cell death, reducing inflammation, and enhancing synaptic plasticity. Strategies include lifestyle modifications, nutritional supplementation, and pharmacological interventions to mitigate effects of aging, neurodegenerative diseases, stroke, and traumatic brain injury.
Neuroprotective effects safeguard brain cells from damage, potentially improving cognitive function and preventing neurodegenerative diseases. This is achieved through antioxidant, anti-inflammatory, and neuronal survival support mechanisms.
NR supplementation boosts NAD+ levels, a crucial coenzyme involved in energy metabolism, DNA repair, and cell signaling. Increased NAD+ supports cellular function and overall health.
NR boosts NAD+ levels, enhancing mitochondrial function and cellular energy production. This may result in increased vitality and reduced fatigue.
NAD+ boosts sirtuin activity, which are proteins involved in regulating aging. Supplementing with NR to increase NAD+ might promote healthy aging and longevity, though more research is needed.
Ceramides improve skin elasticity and reduce the appearance of fine lines and wrinkles by enhancing hydration and fortifying the skin's barrier function. This leads to a more youthful appearance.
Supplementation with NMN is thought to increase NAD+ levels, a crucial coenzyme for cellular energy metabolism and DNA repair. Boosting NAD+ supports cellular health and may offer anti-aging benefits.
NMN boosts NAD+ levels, potentially enhancing cellular energy production and metabolism. This may lead to reduced fatigue and improved physical performance.
Possible Side Effects
Headache is pain in the head ranging from mild to severe, potentially with nausea, light/sound sensitivity, or dizziness. It can be caused by tension, dehydration, stress, or medication side effects, and persistent headaches require medical evaluation.
Nausea is an unpleasant sensation of stomach unease, often preceding vomiting, caused by various factors like medications or infections. Prolonged nausea can lead to complications like dehydration.
Flushing is a temporary redness of the skin, similar to a niacin flush, experienced by some individuals after taking NR. It's generally harmless and resolves on its own.
Scientific Evidence
Studies on NR and NAD+ in humans and animal models, including clinical trials assessing the effects of NR supplementation on NAD+ levels and various health outcomes. Specific sources include research articles published in peer-reviewed scientific journals such as Nature, Cell Metabolism, and the Journal of Nutritional Biochemistry.
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