Gamma-linolenic acid (GLA) may support skin health and reduce inflammation, but can cause gastrointestinal side effects.
Gamma-linolenic acid (GLA) is an omega-6 fatty acid found in certain plant seed oils. It's often used as a dietary supplement to potentially support skin health, reduce inflammation, and alleviate symptoms associated with conditions like eczema, neuropathy, and rheumatoid arthritis. While generally considered safe, some individuals may experience mild gastrointestinal side effects or an increased risk of bleeding. Further research is needed to fully understand its efficacy and long-term effects.
Key Information
Inside Body Harmful Score
Common Dosage
200-600mg daily
Source Type
natural
Production Process
Gamma-linolenic acid (GLA) is primarily extracted from plant seed oils, such as evening primrose oil, borage oil, and black currant seed oil. These oils are processed to isolate and concentrate the GLA component, often through solvent extraction or cold-pressing techniques.
Use Type
Inside BodyPotential Benefits
This benefit focuses on decreasing inflammation throughout the body by lowering inflammatory markers, alleviating symptoms of chronic inflammation, and promoting healthy tissue and organ function. It aims to reduce pain, improve movement, and lower the chances of developing long-term diseases related to inflammation.
This benefit aims to improve overall skin health and appearance through increased hydration, reduced inflammation, improved elasticity, and protection from environmental damage. Healthy skin exhibits a smooth texture, even tone, and strong barrier function.
GLA may alleviate diabetic neuropathy symptoms like nerve pain and numbness by supporting nerve cell function and reducing inflammation. This is potentially due to GLA's role in the production of anti-inflammatory prostaglandins.
GLA may reduce joint pain and inflammation in rheumatoid arthritis due to its anti-inflammatory properties. It works by modulating the inflammatory response in the joints.
Possible Side Effects
Gastrointestinal upset involves a variety of digestive symptoms like nausea, diarrhea, and abdominal pain. It can range from mild discomfort to severe pain and may indicate an underlying condition if persistent.
Headache is pain in the head ranging from mild to severe, potentially with nausea, light/sound sensitivity, or dizziness. It can be caused by tension, dehydration, stress, or medication side effects, and persistent headaches require medical evaluation.
Evening Primrose Oil may increase the risk of bleeding due to its antiplatelet effects. This is particularly concerning for those taking blood thinners or undergoing surgery.
Scientific Evidence
Numerous studies have investigated GLA, including those published in journals like the *American Journal of Clinical Nutrition*, *Lipids*, and *Prostaglandins, Leukotrienes and Essential Fatty Acids*. These studies explore GLA's impact on inflammation, skin health, and specific conditions like diabetic neuropathy and rheumatoid arthritis. Meta-analyses and systematic reviews provide further insights into the collective evidence.
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