Typical dose
As an excipient: amounts vary widely by formulat...
Oral & topical
Oral safety: low
Skin safety: harmless
About this supplement
Mannitol with Sorbitol refers to a combination of two sugar alcohols (polyols) commonly used together in pharmaceutical, supplement, and cosmetic formulations. Mannitol (C6H14O6) and sorbitol (C6H14O6) are isomers with similar physical properties but distinct metabolic pathways. This combination is frequently employed as a multi-functional excipient: as a bulking agent, sweetener, humectant, stabilizer, and osmotic agent. In supplements, it serves as a filler/diluent for powders and tablets. In beauty products, it acts as a moisturizer and viscosity modifier. The blend leverages the complementary properties of both polyols—mannitol's lower hygroscopicity and sorbitol's higher moisture retention—to achieve specific textural and stability outcomes.
How much to take
- Typical amount
- As an excipient: amounts vary widely by formulation (e.g., 10-90% in chewable tablets). Not typically consumed as a primary active ingredient.
- Suggested range
- No established recommended dosage as a nutrient. As an additive, usage follows GRAS limits and formulation needs.
Potential benefits
Benefits linked to this supplement form:
Things to watch for
Possible side effects linked to this form:
Health goals
Needs and goals this form may help with:
Other forms of Mannitol
Compare absorption and active amounts with sibling forms:
Technical details â–Ľ
Chemical ID (CAS)
69-65-8 (Mannitol); 50-70-4 (Sorbitol); combination typically not assigned a unique CAS
Physical properties
White, crystalline powder or granules. Sweet taste. Highly soluble in water. Hygroscopic (sorbitol more so than mannitol). Stable under normal conditions.
How it’s made
Typically produced synthetically via catalytic hydrogenation of sugar sources. Mannitol is derived from fructose (often from corn syrup) via high-pressure hydrogenation. Sorbitol is derived from glucose. The two are then blended in specific ratios for intended application.