Typical dose
Dosage varies widely by indication. For reductio...
Oral & topical
Oral safety: low
Skin safety: harmless
About this supplement
Mannitol Injection is a sterile, aqueous solution of mannitol, a sugar alcohol (polyol), intended for intravenous administration. It functions primarily as an osmotic diuretic and renal diagnostic agent. When administered intravenously, mannitol increases the osmolarity of plasma and glomerular filtrate, promoting diuresis by inhibiting tubular reabsorption of water and electrolytes. It is also used to reduce intracranial and intraocular pressure, as a renal function test, and to promote the excretion of toxic substances. The injection form is typically available in concentrations ranging from 5% to 25%.
How much to take
- Typical amount
- Dosage varies widely by indication. For reduction of intracranial pressure: 0.25-2 g/kg as a 15-25% solution IV over 30-60 min. As a diuretic: 50-200 g over 24 hours as a 5-25% solution. Must be individualized based on patient condition.
- Suggested range
- 0.25 g/kg to 2 g/kg per dose, administered intravenously. Total daily dose typically does not exceed 200 g.
Potential benefits
Benefits linked to this supplement form:
Things to watch for
Possible side effects linked to this form:
Health goals
Needs and goals this form may help with:
Other forms of Mannitol
Compare absorption and active amounts with sibling forms:
Technical details â–¼
Chemical ID (CAS)
69-65-8
Physical properties
In its pure form, mannitol is a white, crystalline powder or free-flowing granules. It is odorless, has a sweet taste, and is freely soluble in water. The injection is a clear, colorless to slightly yellow aqueous solution.
How it’s made
Mannitol is produced industrially by the high-pressure hydrogenation of fructose/glucose syrups derived from starch, using a nickel catalyst. For pharmaceutical injection, the synthesized mannitol is highly purified, dissolved in Water for Injection, sterilized by filtration, and aseptically filled into vials or bags.