Diindolylmethane (DIM) is a naturally occurring compound formed during the digestion of indole-3-carbinol (I3C), which is found in cruciferous vegetables. It is available as a dietary supplement and i...
Diindolylmethane (DIM) is a naturally occurring compound formed during the digestion of indole-3-carbinol (I3C), which is found in cruciferous vegetables. It is available as a dietary supplement and is believed to influence estrogen metabolism, potentially shifting the balance towards more beneficial estrogen metabolites. While research is ongoing, DIM is also investigated for its antioxidant, anti-inflammatory, and potential anticancer properties. Common side effects are generally mild.
Key Information
Inside Body Harmful Score
Common Dosage
100-300mg daily
Source Type
natural
Production Process
DIM is naturally produced in the body from the digestion of indole-3-carbinol (I3C), a compound found in cruciferous vegetables such as broccoli, cauliflower, and cabbage. It can also be synthesized in a laboratory.
Use Type
Inside BodyPotential Benefits
Reduces inflammation by inhibiting inflammatory pathways and the production of inflammatory molecules, thereby alleviating symptoms and protecting against tissue damage. This benefit helps modulate inflammatory responses and promote resolution.
Aged garlic extract acts as an antioxidant by neutralizing free radicals, protecting cells from damage and potentially reducing the risk of chronic diseases. The allicin-derived metabolites are the active components.
DIM is believed to promote beneficial estrogen metabolism by increasing the ratio of 2-hydroxyestrone to 16-alpha-hydroxyestrone. This may lead to improved hormone balance and potential cancer prevention benefits.
Preliminary research suggests DIM may possess anticancer properties by inhibiting cancer cell growth and spread. More research is needed to validate these findings.
Possible Side Effects
Gastrointestinal upset involves a variety of digestive symptoms like nausea, diarrhea, and abdominal pain. It can range from mild discomfort to severe pain and may indicate an underlying condition if persistent.
Headache is pain in the head ranging from mild to severe, potentially with nausea, light/sound sensitivity, or dizziness. It can be caused by tension, dehydration, stress, or medication side effects, and persistent headaches require medical evaluation.
Urine may change to an orange or reddish color. This is usually harmless but should be distinguished from blood in the urine.
Scientific Evidence
Bradlow HL, Sepkovic DW, Telang NT, Osborne MP. Indole-3-carbinol. Adv Exp Med Biol. 1999;472:183-92. PMID: 10719748; Zeligs MA, Fulfaro F, Carducci MA. Review of clinical studies of diindolylmethane (DIM) in cancer prevention and treatment. Nutr Cancer. 2023;75(6):1341-1353. doi: 10.1080/01635581.2022.2113924. Epub 2022 Aug 25. PMID: 36001585.
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