Ubiquinol, the active form of CoQ10, boosts cellular energy production with superior bioavailability, benefiting cardiovascular health.
Ubiquinol is the reduced, active antioxidant form of Coenzyme Q10 (CoQ10), a naturally occurring compound essential for cellular energy production, particularly within the mitochondria. As we age, the body's ability to convert CoQ10 (ubiquinone) to ubiquinol decreases, making direct ubiquinol supplementation potentially more beneficial for older adults and those with certain health conditions. Ubiquinol offers superior bioavailability compared to ubiquinone and is primarily known for its role in supporting cardiovascular health, neurological function, fertility, and reducing statin-induced side effects. While generally safe, some individuals may experience mild gastrointestinal issues.
Key Information
Outside Body Harmful Score
Common Dosage
100-600mg daily, often divided into multiple doses
Source Type
natural
Production Process
Ubiquinol, the reduced form of CoQ10, is produced through a fermentation process followed by chemical reduction to convert ubiquinone to ubiquinol. The manufacturing process also often includes encapsulation to improve bioavailability due to its poor water solubility.
Use Type
Outside BodyPotential Benefits
Cardiovascular health ensures efficient blood circulation by maintaining healthy heart and blood vessels. Benefits include reduced risk of heart disease and stroke through improved blood flow and heart function.
Migraine prevention aims to decrease the frequency, severity, and duration of migraines through lifestyle changes, nutrition, and/or medication. The goal is to stabilize neurological function and reduce reliance on acute treatments, thereby improving quality of life.
Neuroprotection aims to protect the brain and nervous system from damage and degeneration by preventing neuronal cell death, reducing inflammation, and enhancing synaptic plasticity. Strategies include lifestyle modifications, nutritional supplementation, and pharmacological interventions to mitigate effects of aging, neurodegenerative diseases, stroke, and traumatic brain injury.
CoQ10's antioxidant properties may improve sperm quality in men and egg quality in women by protecting against oxidative damage. This can potentially enhance fertility.
CoQ10 supplementation may reduce muscle pain and weakness experienced by individuals taking statin medications. Statins can deplete CoQ10 levels, and supplementation aims to restore these levels and improve muscle function.
Possible Side Effects
Gastrointestinal upset involves a variety of digestive symptoms like nausea, diarrhea, and abdominal pain. It can range from mild discomfort to severe pain and may indicate an underlying condition if persistent.
Insomnia is a sleep disorder involving difficulty falling or staying asleep, leading to non-restorative sleep. It can be triggered by various factors and can result in daytime fatigue and impaired cognitive function.
A mild, typically non-itchy skin rash, characterized by small bumps or red patches, can occur in some individuals, especially with high doses. It usually resolves spontaneously within a few days to weeks.
Scientific Evidence
Crane, F. L. (2001). Biochemical functions of coenzyme Q10. Journal of the American College of Nutrition, 20(6), 591-598. Littarru, G. P., & Tiano, L. (2007). Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Molecular biotechnology, 37(1), 31-37. Soja, A. M., & Mortensen, S. A. (1997). Coenzyme Q10 in cardiovascular disease. Molecular aspects of medicine, 18 Suppl, S159-S168. Arenas-Jal, M., Suñé-Negre, J. M., & García-Montoya, E. (2020). Coenzyme Q10 supplementation: Clinical implications and bioavailability. Antioxidants, 9(7), 649.
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