Potassium Azeloyl Diglycinate improves azelaic acid's tolerability, brightening skin and controlling sebum with potential mild irritation.
Potassium Azeloyl Diglycinate is a water-soluble, synthetic derivative of azelaic acid designed for improved bioavailability and tolerability in skincare applications. It is primarily used topically for its skin brightening, sebum-controlling, anti-inflammatory, and hydrating properties. Preliminary to moderate scientific evidence supports these benefits. While generally well-tolerated, some individuals may experience mild skin irritation or dryness.
Key Information
Outside Body Harmful Score
Common Dosage
Typically used in topical skincare formulations at concentrations between 1% and 10%.
Source Type
synthetic
Production Process
Synthesized by combining azelaic acid with glycine and potassium hydroxide, resulting in a water-soluble derivative.
Use Type
Outside BodyPotential Benefits
Hydration ensures sufficient body water for optimal function, supporting processes like temperature regulation and nutrient transport. It prevents dehydration and associated symptoms like fatigue and cognitive impairment.
Reduces inflammation throughout the body, addressing the root cause of many diseases. Modulates inflammatory pathways and promotes tissue healing.
This benefit reduces inflammation by modulating inflammatory pathways and inhibiting pro-inflammatory cytokines, resulting in reduced pain, swelling, and improved function. It is beneficial for conditions like arthritis, inflammatory bowel disease, cardiovascular disease, and skin conditions.
Skin brightening aims to lighten skin tone and reduce hyperpigmentation through melanin inhibition, exfoliation, and protection against UV damage. This results in a more even and radiant complexion.
This benefit regulates sebum production in the skin, reducing oiliness and preventing acne. It involves various mechanisms that affect sebaceous gland activity and lipid synthesis.
Possible Side Effects
Skin irritation involves symptoms like redness, itching, and rashes due to contact with irritants, allergens, or environmental factors. Severity varies based on the cause, individual sensitivity, and affected area; persistent cases may lead to secondary infections.
Dryness refers to a reduction in moisture content in tissues or organs, leading to symptoms like dry skin, mouth, or eyes. It can be caused by various factors, including environmental conditions, medical conditions, or medications.
Scientific Evidence
Limited number of published studies available. Evidence consists primarily of in-vitro studies and small clinical trials. More robust research is needed to confirm efficacy and long-term safety. Studies focusing on azelaic acid provide indirect support.
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