DHEA supplementation may offer antidepressant effects, particularly in individuals with lower DHEA levels, potentially by influencing neurotransmitter activity. The effects are thought to be linked to the modulation of GABAergic and glutamatergic neurotransmission.
DHEA (Dehydroepiandrosterone) is a naturally occurring hormone that serves as a precursor to other hormones, including testosterone and estrogen. Some studies suggest that DHEA supplementation may have antidepressant effects by influencing neurotransmitter activity and neurosteroid production in the brain. It's hypothesized that DHEA can modulate GABAergic and glutamatergic neurotransmission, potentially leading to improvements in mood and a reduction in depressive symptoms. Individuals with lower DHEA levels may experience a greater benefit from supplementation.