DHEA

DHEA supplementation may improve bone mineral density, especially in older adults and particularly in women, potentially reducing osteoporosis risk. This is thought to be due to DHEA's conversion into estrogen and testosterone, which are important for bone health.

DHEA supplementation may offer antidepressant effects, particularly in individuals with lower DHEA levels, potentially by influencing neurotransmitter activity. The effects are thought to be linked to the modulation of GABAergic and glutamatergic neurotransmission.

DHEA may help reduce disease activity and improve quality of life in individuals with SLE by modulating the immune system and reducing inflammation. It potentially alleviates fatigue and musculoskeletal pain.