Weakness/Fatigue

Excessive vitamin D3 intake can paradoxically lead to weakness and fatigue due to disrupted calcium homeostasis affecting nerve and muscle function. This can be accompanied by other symptoms of vitamin D3 toxicity.

Weakness and fatigue, characterized by a lack of energy and a feeling of tiredness or exhaustion, can paradoxically occur with excessive vitamin D3 intake. While vitamin D3 is essential for energy production and muscle function, excessively high levels in the blood can disrupt calcium homeostasis. This disruption can interfere with nerve and muscle function, leading to generalized weakness, fatigue, and lethargy. This side effect is often accompanied by other symptoms of vitamin D3 toxicity, such as nausea, vomiting, constipation, and increased thirst. The severity can vary depending on the level of excess vitamin D3 and individual sensitivity.