Systemic Toxicity (Rare)

Rare but serious systemic toxicity can occur from excessive topical salicylate use, leading to salicylate poisoning. Symptoms range from nausea and tinnitus to seizures and coma, with children and the elderly being more vulnerable.

Systemic toxicity from topical salicylates, though rare, arises from excessive or prolonged use, especially on large skin areas or compromised skin barriers. The salicylate is absorbed into the bloodstream, leading to salicylate poisoning (salicylism). Symptoms manifest as nausea, vomiting, tinnitus (ringing in the ears), headache, hyperventilation (rapid, deep breathing), confusion, lethargy, disorientation, and in severe cases, seizures, coma, and even death. Children and the elderly are particularly vulnerable due to their different metabolic rates and kidney function.