Phenylketonuria (PKU) Warning

Aspartame contains phenylalanine, which can accumulate to dangerous levels in individuals with phenylketonuria (PKU), a rare genetic disorder. Individuals with PKU must avoid aspartame-containing products to prevent serious health complications.

Phenylketonuria (PKU) is a rare inherited metabolic disorder caused by a deficiency in the enzyme phenylalanine hydroxylase (PAH). This enzyme is necessary to break down phenylalanine, an amino acid found in many foods. Without sufficient PAH, phenylalanine builds up in the body, leading to serious health problems, including intellectual disability, seizures, behavioral problems, and psychiatric disorders. Individuals with PKU must adhere to a strict diet low in phenylalanine throughout their lives to prevent these complications. Aspartame, an artificial sweetener, contains phenylalanine and must be strictly avoided by individuals with PKU to prevent phenylalanine levels from rising to dangerous levels.