Neurological Effects (High Doses)

High doses of oral manganese supplements, especially in individuals with liver dysfunction, can potentially cause neurological issues similar to Parkinson's disease, including tremors and cognitive impairment. This is less common than with inhalation exposure but still poses a risk with chronic over-supplementation.

Excessive oral intake of manganese supplements, particularly in individuals with pre-existing liver dysfunction, can lead to a range of neurological issues. These effects may include symptoms resembling Parkinson's disease, such as tremors, rigidity, slow movement (bradykinesia), and postural instability. Cognitive impairments, mood changes, and psychiatric symptoms have also been reported in some cases. While less common than neurological effects resulting from manganese inhalation (e.g., in occupational settings), chronic over-supplementation can still pose a risk, especially when the body's ability to metabolize and excrete manganese is compromised.