Nausea/Vomiting

Vitamin D3 supplementation, especially at high doses, can cause nausea and vomiting due to hypercalcemia stimulating the brain's chemoreceptor trigger zone. Severity can range from mild discomfort to pronounced emesis, and prompt reporting to a healthcare provider is advised.

Nausea and vomiting are potential side effects associated with vitamin D3 supplementation, particularly at high doses. These gastrointestinal disturbances are thought to arise from the vitamin's effect on calcium absorption, leading to hypercalcemia in some individuals. Hypercalcemia can stimulate the chemoreceptor trigger zone (CTZ) in the brain, which controls nausea and vomiting. The severity can range from mild discomfort to more pronounced emesis. Other contributing factors may include individual sensitivity, pre-existing gastrointestinal conditions, or interactions with other medications. The precise mechanism, frequency, and severity can vary substantially between individuals. Prolonged or severe nausea/vomiting can lead to dehydration, electrolyte imbalances, and reduced quality of life. Symptoms should be promptly reported to a healthcare provider, especially in vulnerable populations such as infants, the elderly, and those with pre-existing medical conditions.