Liver Toxicity (Rare)

High doses of reishi, in very rare cases, can cause liver toxicity, especially in individuals with pre-existing liver conditions. Symptoms include jaundice, abdominal pain, and fatigue.

Liver toxicity, although rare, is a serious adverse effect associated with reishi mushroom consumption, particularly at high doses. Symptoms may include jaundice (yellowing of the skin and eyes), abdominal pain, nausea, vomiting, fatigue, dark urine, and pale stools. The underlying mechanism may involve drug-induced liver injury (DILI) or interference with liver metabolic processes. Individuals with pre-existing liver conditions are at significantly higher risk. Monitoring liver function tests is crucial if symptoms appear.