Interaction with MAO Inhibitors

Interaction with MAO inhibitors can cause a hypertensive crisis due to increased neurotransmitter levels, resulting in dangerously high blood pressure. This condition can lead to severe cardiovascular events and requires immediate medical attention.

The interaction with Monoamine Oxidase Inhibitors (MAOIs) can lead to a hypertensive crisis, a severe and potentially life-threatening condition characterized by a sudden and dangerous increase in blood pressure. This occurs because MAOIs inhibit the enzyme monoamine oxidase, which is responsible for breaking down neurotransmitters like serotonin, norepinephrine, and dopamine. When combined with substances that increase these neurotransmitters, the excess can overwhelm the body, leading to vasoconstriction and elevated blood pressure. Symptoms of a hypertensive crisis include severe headache, stiff neck, nausea, vomiting, sweating, palpitations, and rapid heart rate. In severe cases, it can lead to stroke, heart attack, or death.