Increased risk of prostate cancer

High-dose vitamin E supplementation may be associated with an increased risk of prostate cancer in men, though this finding is controversial and requires further research. The risk appears to be associated with long-term, high doses.

Several studies have suggested a potential association between high-dose vitamin E supplementation and an elevated risk of developing prostate cancer in men. This finding remains controversial and requires further investigation to establish a definitive causal relationship. Current research is inconclusive regarding the specific mechanisms involved, but oxidative stress and hormonal pathways are being explored. It is important to note that the observed increase in risk is generally associated with long-term, high-dose supplementation rather than dietary intake of vitamin E or low to moderate supplementation.