Bronchospasm

Inhaled NAC can trigger bronchospasm, especially in asthmatics, causing wheezing and breathing difficulties. This involves airway constriction and irritation.

Bronchospasm is the constriction of the airways in the lungs, making it difficult to breathe. Symptoms include wheezing, shortness of breath, chest tightness, and coughing. In the context of inhaled N-acetylcysteine (NAC), bronchospasm can occur as a paradoxical reaction, particularly in individuals with pre-existing respiratory conditions such as asthma. The mechanism is not fully understood, but it may involve the irritant effect of NAC on the airways, triggering inflammation and smooth muscle contraction.