Bioavailability Concerns

High concentrations of magnesium stearate *may* inhibit nutrient absorption *in vitro*, but human trials show minimal risk at supplement concentrations. The significance of this effect is currently uncertain.

In vitro studies have suggested that magnesium stearate, at high concentrations, may inhibit nutrient absorption. However, these effects have not been consistently replicated in human trials. The low concentrations of magnesium stearate typically found in dietary supplements are generally considered to pose minimal risk to nutrient bioavailability. The clinical significance of these in vitro findings remains uncertain in real-world supplementation scenarios.