Vitamin K1 (Phylloquinone) is crucial for blood clotting and may benefit bones, but can interact with anticoagulants.
Vitamin K1 (Phylloquinone) is a fat-soluble vitamin primarily obtained from green leafy vegetables. It is vital for blood coagulation as a cofactor for enzymes involved in the synthesis of clotting factors. It also contributes to bone health by supporting osteocalcin carboxylation, although further research is required to fully elucidate this effect. While generally safe, Vitamin K1 can significantly interact with anticoagulant medications, necessitating careful monitoring and consistent intake for individuals on such therapies. Recommended daily intake varies based on age, sex, and overall health.
Key Information
Inside Body Harmful Score
Common Dosage
75-120 mcg daily, varies based on age, sex, and health status
Source Type
natural
Production Process
Vitamin K1 is primarily extracted from green leafy vegetables. It can also be synthesized, although extraction from natural sources is more common.
Use Type
Inside BodyPotential Benefits
Enhances bone density, strength, and integrity by supporting bone formation, calcium absorption, and reducing age-related bone loss. Improves overall skeletal health and function, ultimately reducing the risk of fractures.
Blood clotting is a vital process that stops bleeding after injury by forming a stable clot. It involves a complex interaction of platelets and clotting factors.
Possible Side Effects
Allergic reactions are hypersensitivity responses to allergens, ranging from mild skin irritation to life-threatening anaphylaxis. Symptoms vary widely and are caused by an immune response.
Interference with blood thinners can lead to increased bleeding risk or increased clot formation, potentially causing severe health complications. Regular monitoring is crucial when other substances are introduced alongside anticoagulants.
Drug interactions can alter a drug's effectiveness, leading to either increased risk of blood clots or bleeding, particularly with anticoagulants. Monitoring is essential to manage these interactions.
Vitamin K1 is generally safe with rare adverse effects. Allergic reactions are possible, especially with intravenous administration, and high doses may interact with anticoagulants.
Scientific Evidence
Shearer MJ. Vitamin K. Lancet. 1995 Nov 18;346(8982):1144-9; Vermeer C. Gamma-carboxyglutamate-containing proteins and the vitamin K-dependent carboxylase. Physiol Rev. 1996 Oct;76(4):1151-315.
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