Sh-Oligopeptide-1 (EGF) is a synthetic peptide that promotes skin rejuvenation and wound healing, but may cause irritation.
Sh-Oligopeptide-1 (EGF), a synthetically produced peptide mimicking natural Epidermal Growth Factor, is utilized in topical cosmetic products for its potential skin rejuvenating properties. It stimulates cell growth and collagen production, aiding in wound healing and scar reduction. While generally safe for topical application, potential side effects include skin irritation and acne flare-ups. Theoretical concerns exist regarding its potential to stimulate tumor growth, but evidence supporting this in topical cosmetic use is limited. Dosage depends on the specific product and concentration.
Key Information
Outside Body Harmful Score
Common Dosage
Dosage varies significantly depending on the product concentration and intended use; typically provided as a percentage of the formulation (e.g., 0.001% - 0.01%).
Source Type
synthetic
Production Process
Synthesized via recombinant DNA technology, often using bacteria or yeast to produce the peptide sequence.
Use Type
Outside BodyPotential Benefits
Accelerates and supports the body's natural wound repair processes. This includes reducing inflammation, promoting collagen synthesis, increasing cell proliferation, and facilitating angiogenesis, leading to faster wound closure, reduced scarring, and decreased infection risk.
Skin rejuvenation improves skin health and appearance by reducing wrinkles, improving texture and tone, addressing discoloration, and treating acne. It works by stimulating collagen production, increasing cell turnover, improving hydration, and reducing inflammation.
Rosehip oil may reduce the appearance of scars, including surgical and acne scars, by promoting skin regeneration and reducing inflammation and discoloration. Its fatty acids and antioxidants aid in the healing process and improve skin texture.
Palmitoyl Pentapeptide-4 boosts collagen production by mimicking damaged collagen. This leads to reduced wrinkles and improved skin elasticity.
Possible Side Effects
Skin irritation involves symptoms like redness, itching, and rashes due to contact with irritants, allergens, or environmental factors. Severity varies based on the cause, individual sensitivity, and affected area; persistent cases may lead to secondary infections.
EGF may stimulate excessive cell growth, potentially leading to acne flare-ups in acne-prone individuals due to increased sebum production and clogged pores. This results in an increase in pimples, blackheads and inflammation.
Theoretical concerns exist that topical EGF could stimulate the growth of pre-existing cancerous cells. This risk is largely unproven for cosmetic use but warrants caution.
Scientific Evidence
Ricardo G. Azizkhan, Kenneth W. Sloan, and George K. Tompson. Topical Epidermal Growth Factor Accelerates Wound Healing. Journal of Burn Care & Rehabilitation, Vol. 13, No. 6, 1992, 625-630. R. Nanney. Epidermal growth factor. J Burn Care Rehabil. 1993 Jan-Feb;14(1):91-103. Pastar I, Stojadinovic O, Izadpanah A, et al. Epidermal growth factor and its receptors: structure, function, and role in wound healing. Adv Wound Care (New Rochelle). 2014;3(1):21-30.
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