Key Information
Inside Body Harmful Score
Use Type
Inside BodyPotential Benefits
Niacin aids in cholesterol management by lowering LDL and VLDL cholesterol while increasing HDL cholesterol. It inhibits fat breakdown in adipose tissue, which reduces LDL and VLDL production.
Niacin prevents and treats pellagra by replenishing NAD and NADP, essential coenzymes for cellular metabolism. This resolves the characteristic symptoms of dermatitis, diarrhea, and dementia associated with the deficiency.
Possible Side Effects
Niacin flush is a common side effect of nicotinic acid (vitamin B3) supplementation, causing redness, warmth, itching, and tingling on the skin due to prostaglandin release and blood vessel dilation. Symptoms are typically mild to moderately uncomfortable and resolve within a few hours.
High doses of niacin can cause liver inflammation and damage, potentially leading to liver failure. Monitoring liver function is crucial during high-dose niacin supplementation.
Niacin can increase blood sugar levels by affecting insulin resistance and glucose metabolism. This is particularly concerning for individuals with diabetes or glucose intolerance.
Niacin can increase uric acid levels due to impaired kidney excretion, potentially exacerbating gout and leading to joint pain and inflammation. Chronic elevation may cause kidney issues.
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