Nattokinase is an enzyme that dissolves blood clots, potentially improving cardiovascular health, but increasing bleeding risk.
Nattokinase is an enzyme derived from fermented soybeans, primarily known for its fibrinolytic (blood clot dissolving) properties. Research suggests potential benefits for cardiovascular health, including blood pressure reduction and improved blood flow. However, the primary risk is increased bleeding, especially when combined with other blood-thinning agents. Individuals with bleeding disorders, soy allergies, or those taking anticoagulants should exercise caution or avoid nattokinase. Consult with a healthcare professional before use.
Key Information
Inside Body Harmful Score
Common Dosage
100-200mg daily
Source Type
natural
Production Process
Nattokinase is produced by fermenting soybeans with Bacillus subtilis natto. This bacteria produces the enzyme, which is then extracted and purified.
Use Type
Inside BodyPotential Benefits
Cardiovascular health ensures efficient blood circulation by maintaining healthy heart and blood vessels. Benefits include reduced risk of heart disease and stroke through improved blood flow and heart function.
L-Citrulline increases nitric oxide production, leading to vasodilation and improved blood flow. This enhances oxygen delivery throughout the body.
GABA may lower blood pressure in hypertensive individuals by acting as an inhibitory neurotransmitter and promoting vasodilation. It reduces neuronal excitability, influencing the autonomic nervous system to regulate vascular tone.
Nattokinase dissolves fibrin, a key component of blood clots, thereby improving blood flow and reducing the risk of thrombosis. This is achieved through the direct enzymatic breakdown of fibrin.
Nattokinase may reduce plaque formation in arteries, potentially inhibiting atherosclerosis progression. More research is needed to confirm these preliminary findings.
Nattokinase may decrease blood viscosity by breaking down fibrin, improving blood flow. This can potentially enhance circulation and reduce the risk of blood clots.
Possible Side Effects
Gastrointestinal upset involves a variety of digestive symptoms like nausea, diarrhea, and abdominal pain. It can range from mild discomfort to severe pain and may indicate an underlying condition if persistent.
Allergic reactions are hypersensitivity responses to allergens, ranging from mild skin irritation to life-threatening anaphylaxis. Symptoms vary widely and are caused by an immune response.
Increased bleeding risk occurs due to interference with blood clotting, potentially leading to prolonged bleeding, easy bruising, or internal bleeding. This risk is amplified by anticoagulant/antiplatelet medications or pre-existing bleeding disorders.
Gastrointestinal discomfort includes nausea, bloating, and diarrhea, typically mild and transient. Symptoms are often dose-dependent and vary in severity.
Scientific Evidence
Studies on nattokinase have been published in journals such as Hypertension Research, Journal of Physiological Anthropology, and Integrative Medicine. Further research, including large-scale clinical trials, is needed to confirm its long-term efficacy and safety.
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